Who Do You Think You Are?: Recovering the Self in the Working Class Escape Narrative (2025)

Re-evaluation of exercise-induced muscle soreness : an immunohistochemical and ultrastructural study

2003

In Sweden by Solfjädern Offset AB Umeå Cover picture: A longitudinal section of the soleus muscle from an exercised subject showing extra-sarcomeres revealed by staining for alpha-actinin (green) and desmin (green)

A Randomized Double-Blind Placebo Controlled Clinical Trial Evaluating the Effects of an Investigational Study Product on Exercise Induced Muscle Soreness, Markers of Inflammation, Muscle Damage and Exercise Performance in Healthy Males

Journal of nutrition and health sciences, 2018

Delayed Onset of Muscle Soreness and The Activation of The Immune System

Proceedings of the 5th International Seminar of Public Health and Education, ISPHE 2020, 22 July 2020, Universitas Negeri Semarang, Semarang, Indonesia, 2020

Inappropriate exercise prescription is one of many factors to sport injuries. Delayed onset of muscle soreness triggers the inflammatory processes. Therefore knowing the process of DOMS, physical exercise benefits, and the process of immune system activation after physical exercise will give us better understanding to create precise prescription. Original studies within last ten years were considered, other references were used only to support the storylines. The codifying/compilation stage, followed by analysis and synthesis, then analysis to synthesis were performed sequentially to provide acceptable answers. Eccentric contraction and high intensity exercise cause DOMS. DOMS sequences: mechanical damage; inflammation; and free radical proliferation. Physical exercise benefits both in physical and mental health. Neutrophil, macrophages as natural killer cells are types of the main cellular vulnerable congenital of immune system, changed because of physical exercise. Proper methods and intensity in physical exercise are keys to activates immune system.

Effect of bench press exercise intensity on muscle soreness and inflammatory mediators

Journal of Sports Sciences, 2009

Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies

The Journal of Physiology, 2000

Musculoskeletal pain and exercise-challenging existing paradigms and introducing new

British journal of sports medicine, 2018

Traditional pain models that describe tissue pathology as a source of nocioceptive input directly linked with pain expression, have been insufficient for assessing and treating musculoskeletal pain. The need for pain to be avoided or alleviated as much as possible during physical activity has recently been challenged, with a paradigm shift from traditional biomedical models of pain towards a biopsychosocial model of pain.

Assessment of postexercise muscle soreness by electromyography and mechanomyography

Journal of Pain, 2002

Mechanomyography (MMG) and electromyography (EMG) recordings from the first dorsal interosseous muscle of the hand were compared for pre-exercise and immediately after, 24-hour, and 48-hour postexercise muscle soreness. Thirteen healthy male subjects performed progressively increasing number of eccentric contractions from bout 1 (10.34 ؎ 1.96) to bout 6 (27.46 ؎ 5.01) (P < .03) with 116% maximum voluntary contraction (MVC) for provocation of postexercise muscle soreness. Increased areas of pain, reduced pressure pain threshold, reduced MVC, and reduced range of motion were present immediately after as compared with pre-exercise (P < .05). During intense eccentric exercise, root mean squared amplitude values of MMG increased progressively from bout 1 to bout 6, but EMG root mean squared amplitude decreased as the muscle fatigued (P < .05). Time course changes of MMG and EMG root mean squared amplitude values during single concentric, isometric, and eccentric contractions at 0%, 25%, 50%, 75%, and 100% MVC weights were measured in relation to postexercise muscle soreness. The EMG root mean squared amplitude values showed insignificant changes for concentric, isometric, and eccentric contractions between pre-exercise, immediately after, 24 hours, and 48 hours. MMG root mean squared amplitude values increased during concentric, isometric, and eccentric contractions at immediately after as compared to pre-exercise, 24 hours, and 48 hours. At immediately after, 24 hours, and 48 hours the maximum EMG root mean squared amplitude values were achieved at lower MVC levels as compared with pre-exercise (P < .05). MMG root mean squared amplitude findings suggest changes in viscoelastic properties resulting in significant mechanical muscle vibrations after intense eccentric exercise. This may suggest a role of stimulation of mechanosensitive nociceptors in relation to postexercise muscle soreness. It is concluded that simultaneous recordings of MMG and EMG may serve as an appropriate means of studying the relationship between electrical and mechanical muscle activity occurring with postexercise muscle soreness.

The effect of acute and long‐term physical activity on extracellular matrix and serglycin in human skeletal muscle

Physiological Reports, 2015

Remodeling of extracellular matrix (ECM), including regulation of proteoglycans in skeletal muscle can be important for physiological adaptation to exercise. To investigate the effects of acute and long-term exercise on the expression of ECM-related genes and proteoglycans in particular, 26 middleaged, sedentary men underwent a 12 weeks supervised endurance and strength training intervention and two acute, 45 min bicycle tests (70% VO 2 max), one at baseline and one after 12 weeks of training. Total gene expression in biopsies from m. vastus lateralis was measured with deep mRNA sequencing. After 45 min of bicycling approximately 550 gene transcripts were >50% upregulated. Of these, 28 genes (5%) were directly related to ECM. In response to long-term exercise of 12 weeks 289 genes exhibited enhanced expression (>50%) and 20% of them were ECM related. Further analyses of proteoglycan mRNA expression revealed that more than half of the proteoglycans expressed in muscle were significantly enhanced after 12 weeks intervention. The proteoglycan serglycin (SRGN) has not been studied in skeletal muscle and was one of few proteoglycans that showed increased expression after acute (2.2-fold, P < 0.001) as well as long-term exercise (1.4-fold, P < 0.001). Cultured, primary human skeletal muscle cells expressed and secreted SRGN. When the expression of SRGN was knocked down, the expression and secretion of serpin E1 (SERPINE1) increased. In conclusion, acute and especially long-term exercise promotes enhanced expression of several ECM components and proteoglycans. SRGN is a novel exercise-regulated proteoglycan in skeletal muscle with a potential role in exercise adaptation.

Correlation of Delayed Onset Muscle Soreness and Inflammation Post-exercise Induced Muscle Damage

Open Access Macedonian Journal of Medical Sciences

BACKGROUND: Delayed Onset Muscle Soreness (DOMS) is a common injury resulting from abnormal intensive training in athletes, mainly the result of training involving eccentric contractions. AIM: The aim of this study was to determine the correlation between the incidence of DOMS and HMGB1 as a marker of the occurrence of inflammation post Exercise Induces Muscle Damaged. METHOD: 28 male recreational students of Sports Science Department, Universitas Negeri Surabaya who met all inclusion and exclusion criteria participated in this study. Participants completed a muscle damaging exercise which consists of a 10x10 drop jump (DRP) and a bout of 40×15 m sprints with a 5 m deceleration zone (SPR) to obtain a muscle damage effect. In this study, the stretching in the exercise session was not given, this was done to get the DOMS effect after exercise. DOMS and HMGB1 was carry out 1 hour before the exercise, 12 hours after the exercise, 24 hours after the exercise and 48 hours after the exerci...

Remodeling the Skeletal Muscle Extracellular Matrix in Older Age—Effects of Acute Exercise Stimuli on Gene Expression

International Journal of Molecular Sciences

With advancing age, the skeletal muscle extracellular matrix (ECM) undergoes fibrotic changes that may lead to increased muscle stiffness, injury susceptibility and strength loss. This study tested the potential of different exercises to counter these changes by stimulating the activity of genes associated with ECM remodeling. Twenty-six healthy men (66.9 ± 3.9 years) were stratified to two of four groups, performing unilateral (i) conventional resistance exercise, (ii) conventional resistance exercise followed by self-myofascial release (CEBR), (iii) eccentric-only exercise (ECC) or (iv) plyometric jumps (PLY). The non-trained leg served as control. Six hours post-exercise, vastus lateralis muscle biopsy samples were analyzed for the expression of genes associated with ECM collagen synthesis (COL1A1), matrix metallopeptidases (collagen degradation; MMPs) and peptidase inhibitors (TIMP1). Significant between-group differences were found for MMP3, MMP15 and TIMP1, with the greatest r...